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KMID : 1011420220270030177
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Journal of Korean Ophthalmic Optics Society
2022 Volume.27 No. 3 p.177 ~ p.185
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Characteristics Study of Antioxidant Contact Lenses Containing Gallic Acid and Networked with Natural Polysaccharides
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Kim Ga-eun
Lee Hyun-Mee
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Abstract
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Purpose: The purpose of this study was to manufacture hydrogel contact lenses containing gallic acid, a natural antioxidant, and evaluate the characteristics and antioxidant duration of contact lenses networked with natural polysaccharides.
Methods: Hydrogel contact lenses containing gallic acid were polymerized, and then an interpenetrating polymer network was performed with collagen and hyaluronic acid to form a double network and triple network inside the contact lenses. An antioxidation test was conducted by measuring the absorbance using DPPH and the radical scavenging rate. For performance evaluation of the contact lenses, the moisture content, wettability, oxygen permeability, and antibacterial properties were measured.
Results: Contact lenses containing gallic acid had a high radical scavenging rate and antioxidant properties. They also exhibited high wettability, oxygen permeability, and antibacterial properties.
Contact lenses networked with hyaluronic acid improved the wettability. Contact lenses networked with collagen and hyaluronic acid exhibited slightly lowered physical properties, such as moisture content and oxygen permeability; however, contact lenses networked with hyaluronic acid significantly improved the wettability. The improved triplenetworked contact lenses had a relatively low radical scavenging rate but improved antioxidants duration.
Conclusions: It was confirmed that contact lenses containing gallic acid and networked with hyaluronic acid improved wettability and increased antioxidant retention time.
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KEYWORD
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Antioxidant contact lens, Gallic acid, Collagen, Hyaluronic acid, Interpenetrating Polymer Network (IPN)
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